Vitamin C as a Cancer Target (From Wikipedia)

A biologist knows what a LOF mutation is and induces these to study what a gene function is. In the case of natural mutants of the VHF gene, these patients are very prone to cancer disease partially by constitutive activation of HIF. By adding elements (of which vitamin C is one), this process could be reversed:

"Treatment

Suggested targets for VHL-related cancers include targets of the HIF pathway, such as VEGF. Two inhibitors of VEGF sorafenib and sunitinib have recently been approved by the FDA [6]. The mTOR inhibitor rapamycin may also be an option [9]. Bevacizumab, a monoclonal antibody targeting VEGF, is one medication currently undergoing clinical trials

Since iron, 2-oxoglutarate and oxygen are necessary for the inactivation of HIF, it has been theorized that a lack of these cofactors could reduce the ability of hydroxlases in inactivating HIF. A recent study has shown that in cells with a high activation of HIF even in oxygenated environments was reversed by supplying the cells with ascorbate [10]. Thus, Vitamin C may be a potential treatment for HIF induced tumors." (as of 3/25/09) reference 10 being:

^ Knowles HJ, Raval RR, Harris AL, Ratcliffe, PJ. (2003). "Effect of ascorbate on the activity of hypoxia-inducible factor in cancer cells.". Cancer research 63: 1764–8.

Here is the Wikipedia link showing the value of vitamin C as a therapeutic against cancer: http://en.wikipedia.org/wiki/Von_Hippel-Lindau_tumor_suppressor link

Tea Benefits:

(wikipedia entry:)

Tea Boosts

The Warburg Effect

The Warburg Effect, widely recognized by worldwide oncology as the way that human tumors generate their sustenance, is tied into the activation of HIF1-a and vice versa.

It is somewhat of a chicken or egg question of whether anoxia forced aerobic glycolysis or whether carcinogenesis turned on aerobic/anaerobic glycolysis.

This much is true - that HIF-1a is turned on by this process, in effect making cancerous cells immune to the normal genetic programs that destroy mutated and tumorigenic cells.

Vitamin C at physiological levels in fact disables HIF-1a profoundly, thereby inhibiting carcinogenesis before the fact or after the fact.

Reduced Ascorbic Acid is the key to unlocking the nexus between Von Hippel-Lindau Factor (VHF), HIF (hypoxia induced factor), apoptosis, and the cancer disease.

HR 875 bans gardening:

The Presidential Garden

This is a joke right? America BANS gardening and organic farms????

That's ridiculous, evil, and very un-American. Obviously, this is just a joke, because if it were true, that means that evil Nazis have taken over USA and American Agriculture.

Banning Your Backyard?!?

What the heck does this convoluted law really mean?? Why does Monsanto, whose GMO are banned and frowned upon by all of Europe have something to do with this?



Must be a joke.

Don't Worry Prince Charles, Artichoke and Dandelion are Proven Detoxifiers

Prince Charles Detox Tincture

Artichoke is known to increase superoxide dismutase enzymes, the dandelion helps the kidneys in a diuretic action. Both assist the liver, which is the single most important organ in detoxification in tandem to the kidneys.

The critics shall step down.

Bile assistance
Assistance against gallstone
Antioxidant effect

and on and on

Natural products with potent virucidal activity

for human pathogens:

garlic 1

garlic 2

Green Tea Catechin Efficacy 2005

Micromolar MIC50 Catechin Derivatives

Cytokine reactions of the liver with Lp(a)

In chronic, low-level inflammation, there is more Lp(a) generated. In the case of severe burn trauma, Lp(a) is a negatively regulated acute phase reactant. It may be that the normal system is overriden or that it serves a useful purpose to have more proteolysis in this circumstance.

Here is the paper out of Parke-Davis/Warner Lambert

The NIH studies on ascorbic acid selective toxicity to cancer

(Mark Levine's work):

PNAS 2007 paper

PNAS 2008 in vivo work

Of course, this is one of several mechanisms by which it works. So there is scientific basis and demonstration across the board from the tube to the human for the claims on high dose vitamin C.

Obviously, this doesn't end basic research or anything in the fields of immunology, devbio, and regenerative medicine that seem to be making leaps and bounds. It does go to show that there are real foundations for these claims. It is a misfortune that people use health and science as political or emotional gambits of any kind, in any kind of polemic.

A Real MD's account of megascorbate therapy