Tuesday, June 20, 2023

Copper Deficiency Can Cause Heart Failure

Here is some good science out of the British Medical Journal that will spare a lot of good people from a lot of bad grief, mysteriously caused by a simple lack of dietary copper.

Copper deficiency may be a leading cause of ischaemic heart disease 

 

 


Saturday, December 24, 2022

Ethics in Medicine

If our primary goal is to improve the human condition, then propagating suffering is the antithesis to it.  Any behavior that breeds more harm against the oath, "Thou shall do no harm," demonstrates an active flaunting of the ideals of medicine.  A self knighted "Health Foundation" must first actually refrain from harming hundreds of people before seeking out to deploy antique empires in far off places with a favorable international exchange rate where a peanut at home is a pound afar.

It is not a psychiatric playground to ruin yourself and everyone around you in a pyrrhic loss, not even a pyrrhic victory.  You leave that psychological baggage at the doorstep before you enter the hallowed halls of medicine.

It is not a place of judgement and social engineering.  This is not a wooden puppet theater.  This is why there are such explicit protections for belief, orientation, physical traits, gender, etc.  It applies to everyone, not just someone who thinks they are the prince or princess of the building.  I would privately joke about people carrying such fruity airs of faux royalty by prefacing their name with "King" _so and so__/  Even real royals, one who actually visited me from overseas, are not so self-absorbed.  Medicine is meant to heal ailments of the body and mind, not create more of them.

It is not a place to put your ego above the life and death reality of your words.  If you insist on erroneous ideas such as opposing the covid-19 vaccination campaign that has more or less restored normalcy to American life, what you do is indirectly mass murder people by encouraging vaccine denial, thereby allowing the covid-19 virus to be so much more severe and dangerous.  The vaccine turns a once deadly new plague into something like an old cold or flu.  Nobody is going to lug around the mountains of herbs and pints of oils with them all the time in case they catch covid-19.  It is simply more practical to upgrade everyone's immune system to be effective towards covid-19 all the time, without need for reactive herbal extracts which fresh supply you must have on standby at all times - great business model.  Moreover, those magic elixirs factually have not been tested in humans with covid-19 for effectiveness, patent or no patent.  The right to access over the counter herbs, vitamins, minerals, and natural supplements should exist and be maintained as a uniquely American right towards personal health, but these materials should not be construed as a cure without testing them as one first.  To suggest that a patent replaces a clinical trial fools nobody of importance or influence in legal medicine.

It is our place as scientists and those involved in the science to treat it with the utmost sense of responsibility it deserves.  Although the day to day should not be treated like a constant emergency, but with the appropriate amount of urgency or even calm, the fact is that we are dealing with the matters of life and death for some.  It is not a joke for people who have cancer, heart disease, brain ailments, or permanent infections.  It is not a joke for those who have been cosmetically disabled by a disease.  It is not a joke for those whose body is crumbling from underneath their mind long before natural old age.  It is not a game, and for those who abuse and have abused the channels of science as merely a game should read over this from the beginning to the end a few times.

Saturday, September 4, 2021

Novo Nordisk models 2 Time Nobel Prize Winner Linus Pauling's Discovery Between Collagen And Human Atherosclerosis

From the groping in the dark to connecting genes to diseases, Linus Pauling brought the world greater clarity and visibility in biological science.  He was a very intuitive character, pulling things out of the blue which were often correct.  One of his conjectures was that the human collagen synthesis pathway and the lack of the most critical element to this, ascorbate (pronounce it how you will, it is always spelled ascorbate) somehow was the driving force for the majority of human atherosclerosis developed over decades in a lifetime.  Rather than being a sudden, overnight phenomenon where a lump suddenly appears and you keel over from an LAD plaque burst, thrombotic, ischemic "widow maker," these bumps in the artery form over the period of years.  You can even suffer a bunch of these over weeks, and they still won't kill you outright.  Likewise, you don't need any unstable bumps on your arteries for a pothole in the endothelium to cause the same thrombus event by revealing a platelet sticky, damaged basement membrane.

Linus Pauling, being an expert on helical things, found that collagen, a helical thing, is the basis for healthy arteries.  Old histopathology stains are not able to reveal the medial and subendothelial compartment collagens, and so for many decades, many pathologists considered collagen unimportant to arterial integrity until it was glaringly obvious in a fibrotic scar of a plaque.  The Trichromes and Elastin Van Gieson stains in particular generally only detect the adventitial collagen and nothing inside.  The EVG stain suggests that there is perpendicular collagen between the SMC cells, but does not mark the subendothelial collagen.  Where's the collagen???  It is definitely there.  The strongest collagen jacket of an artery is the adventitial layer, so when you have problems there, the artery is in deep trouble.  Some dismiss the adventitia, the collagen jacket of arteries as unimportant to the etiology of atherosclerosis, but when you consider that arteries themselves are fed by arterioles entering and fed through the adventitia, the collagenous adventitia presents itself as essential to the the inner lining health of the artery.  Very simply, all the collagen in an artery is important to its health.  Later immunohistochemistry and EM IHC would clearly show that collagen is a critical structural element in every layer of the human artery.  

Even fibrosis, which is the human body's way of filling in voids of dead and missing cells with a neutral element, rather than leave a giant hole through which massive inappropriate leaks occur, is a life perpetuating phenomenon for the artery and all organs in the body.  A defective, non-functional, excess collagen patch is exceedingly more beneficial than a hemorrhage or even worse, thrombosis hole, in the mathematics of the automatic human biology.  Very imperfect, but also perfect given that sometimes cells cannot divide fast enough to replace a massive loss of them.  

So which one of the many collagens is so important to arterial health, and which is the intersection between Linus Pauling's vitamin C-arterial collagen-arterial health idea?  Col4, which like all collagens requires vitamin C for its integrity.


Novo Nordisk identifies the specific collagen subtype preservation and restoration needed to prevent atherosclerosis (Col4)


Specifically, Linus Pauling cited the amounts of ascorbate that Gulono-y-lactone-oxidase carrying vertebrates are able to upregulate in times of stress that virtually never succumb from heart attacks, strokes, aneurysms, and the rest at the half point in their lifespan.  In these vertebrates, it is totally unheard of for an animal at the equivalent of a human 65 years old to suffer a heart attack, even considering their massive overbearing genetic excess of HDL over LDL.  Eventually, the lack of heart cell regeneration may give way to natural fibrosis and a natural lifespan end, where the heart gives out, but this is not the result of obstructive dietary cholesterol but an innate evolutionary clock.

But there must be a reason for the relative excessive ratio of LDL over HDL in the human organism.  Sri Lankan elephants for example, seem to only have HDL, and are huge vertebrate mammals.  It suggests that an overbearing ratio of LDL to HDL is tantamount to intellectual evolution, pointing to the criticality of cholesterol to the brain at the expense of arterial health.  A true conundrum presents itself, considering that the brain needs its arteries.  A very strange "what if" presents where the insulation upon axons is not cholesterol, but an artery friendly molecule.  In a very vague, out of focus view, what insulation compound is mission critical to the nervous system of vertebrates is needed in a vast excess compared to its dual role in membrane and cell cycle of arterial cells.  Very simply, the amount of cholesterol needed in the brain is far beyond what is needed in the artery, and important amounts of collagen are there in very specific orientations in health.  If the compounds for axon health and artery health were independent, then two things could be made and this problem of one thing being helpful to one system and harmful to another system solved.  A very absurd request of evolutionary processes which for humans are slow - thousands of years.  We're talking about completely re-engineering the lipid genetics of humanity.  In the meantime, we can pull up and pull down our levers with medicine knowing all this.  Is it futile?  NO.  A short, perfect, benevolent life is better than a short, terrible, malevolent, life for humanity.

So if we all plan to live forever, we have to figure out how to both steel our arteries against its pot hole plaster cast, cholesterol, without starving our brains of cholesterol.  It's a true conundrum.

In ending, Linus Pauling's specific recommend for large human adults was no less than 6,000 mg of vitamin C throughout a day, not in one dose but divided throughout a day to at least avoid atherosclerotic problems without other pharmaceutical interventions, specifically to enhance collagen repair within the artery.  Which collagen he didn't know, but Novo Nordisk identifies this to be Collagen IV(4).



   

Monday, August 23, 2021

Decreasing ACE2 Causes Heart Attacks and Strokes

Rather than a natural cognate receptor for covid-19, it is an essential enzyme of the human cardiovascular system that the novel coronavirus uses for cell entry.

The mass murder misinformation campaigns online recommending the reduction of ACE2 and so forth as the solution to the crisis only aggravate the problem of vaccination hesitancy and simple rejection of the vaccine by those who read pseudoscience garbage like this.  These speculations are not even tested upon real covid-19 virus, not even in an in vitro setting.  The fact that groups like this have both slowly turned into political agencies using false science and have found political support in the science community, those with a football fan hooligan mentality but no science between the ears, is deeply concerning to say the least.  The erosion of science by people like this benefits nobody, not in China, not the USA, not Europe, not Russia, nowhere.  All this serves to persuade people to avoid and reject covid-19 vaccination, thereby perpetuating the global crisis.

ACE2 has always served to neutralize the function of excess vasoconstrictor AngII by converting it to Ang1-7, thereby balancing human blood pressure.  If you take away the brakes for the wheels of this system, ACE2, you get strokes, aneurysms, and heart attacks.  Clearly, that could not be the way any beneficial medication, natural or not, works.  To suggest eliminating ACE2 as the solution to the covid-19 pandemic is to suggest mass murder (homicide), and this is no exaggeration.  This person might as well be a guy in a post office with an assault rifle; a malevolent actor and menace to society.

Moreover, decreasing ACE2 WORSENS covid-19, and does not improve it.  Even less than half the available ACE2 is more than enough for a raging covid-19 infection to occur, and so lowering ACE2 simply is not the solution to the covid-19 pandemic crisis.

Decreasing ACE2 WORSENS covid-19 in people. 

My message is unambiguous and clear, and free of any political or personal agenda.  The covid-19 vaccines are the solution to this global crisis.  Please go obtain one if you can.
 
I received the Pfizer mRNA 2 dose vaccine and it is working great without any side effects.  Those close around me have made a sound choice and obtained one of the various vaccines out there and also do not need to rely on prophylactic lice medicine or trading in covid-19 infection for heart attack. 

 

 

 



Sunday, August 8, 2021

Get the covid-19 vaccine, stupid.

Ivermectin is poisonous and has severe side effects.

https://www.drugs.com/ivermectin.html

These desperate suggestions for repurposing small molecules for covid-19 therapy were made before the Pfizer and Moderna covid-19 vaccines existed and were plentiful.  Now, there is simply no excuse not to obtain one and certainly it is totally reckless, irresponsible, and mass homicidal to confuse the non-scientific public about the efficacy and safety of these vaccines.  The disinformation campaign sowing doubt about the very effective vaccines is both deeply disturbing and inexcusable. 

I sprinted out the door and obtained the Pfizer 2 dose covid-19 vaccine as soon as I could and I have never been a more responsible human being in doing so.  All the bizarre conspiracy theories surrounding it are really stupid reading.  Yes, it may have side effects, just like every single human medication, ESPECIALLY ivermectin.  The vaccine has only boosted my health, shielding me from the delta and other covid-19 variants out there without need of a constant stockpile of lice medication at hand.

It's not a political proposition, it's not an either or thing, a right or wrong thing, or a me versus you thing.  Such thinking at a time like this is the EPITOME OF STUPIDITY.  Also, of course you can take high dose vitamin C at the same time, same as you might possibly chew gum and walk at the same time.

Monday, July 27, 2020

Nature Publications: Fucoidan nearly 10 times more potent than Remdesivir (Rensselaer Polytechnic Institute)

Food Seaweeds Contain Fucoidan, A Potent Inhibitor of COVID-19

There is simply no excuse other than malevolent insanity and evil motivations to omit widespread recommendations for dietary supplements to combat this plague via the surgeon general and other officials of the government.

Seaweed, being a green "photosynthetic" plant, not only synthesizes fucoidans, but also vitamin C while it sways merrily in the sunny oceans.

Thursday, July 23, 2020

Megadose Vitamin C, God's Gift, Handicapped Humanity's Cure, and The Bane of The Great Culling (Vitamin C and COVID-19)

Why won't supposedly benevolent government officials tout a ubiquitous, cheap, safe cure over rare, toxic, expensive treatments?  The answers are both obvious, myriad, and evil.  If you are benevolent and have a true agape for the human creature, it is a moral obligation to mention megadose vitamin C as a potential solution to the covid-19 weapon.  The suffering of the people "culled" is a metaphysical debt incurred against the murderers.  There is no net gain, just net loss and bizarre occult curses by INJUST unnatural murder.  There is never a fee to pay by pure, sincere benevolence, but always a debt to pay by doing evil.

The Townsend Letter Regarding Vitamn C and Covid-19

The real question is why is any American government official biasing any artifice product over another? Would that not be the use of government office to unfairly boost one product over another?  Would that not be against fair market force?  It clearly would be.  Combined with the crime of omission of life saving advice by purpose of personal gain, it would amount to a definitive crime of mass genocide and potentially, high treason.