Tuesday, March 2, 2010

Gamma delta T-cells and immune enhancement

This is what not to do:Mevastatin knockdown of yd T cell and corroborates independent lab studies that show that statins are immunosuppressive so much that they are considered as anti-graft-rejection drugs in organ transplant.

Priming these cells with drugs are known to potentiate an anti-cancer effect but not without the usual culprit problems like jaw necrosis.

There are other natural and safe compounds which prime gamma delta T-cells, among which are L-theanine from regular green and black tea. The focus has been on polyphenols that have a plasma threshold much lower than their effective dose, when in fact it might be more bioavailable items in tea that are making the immune system stronger rather than a direct cytotoxic effect by molecules. This being said, these molecules with very low bioavailability may have a profound local effect that is overlooked. In the case of the gastric tract, this is not a small surface area, and it is immunologically dense. The effects of polyphenols that are not seen in plasma may actually be at work in the gut, a very large lymphoid and dendritic site in its own regard. Then there are other components like L-theanine.

By modulating these pathways without drugs, one may enhance the immune system safely and naturally against cancer.

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