Tuesday, March 30, 2010

Growing New Body Parts:

Believe it or not, I spoke to one of the guys at Osiris at a cardiovascular medicine symposium where a large portion of the science paid attention to innate stem cells, those that originate from your own bone marrow. This is actually a failed attempt at immunizing soldiers to bacterial biowarfare agents, as MSC are largely immunosuppressive rather than antigen presenting/T-cell activating. They did find that they are immensely useful at regenerating organs to some degree or another, and preventing graft versus host disease. Maybe it was my imagination or my eyes were playing tricks on me, but I was able to induce bone marrow cells to become beating heart cells at a very, very low rate when they were co-cultured with heart muscle cells in a dish. No point in trying to be persuasive; I leave it that I performed it and saw it. Prove it or disprove it yourself. It is in theory possible to take your bone marrow white blood cells and change them into nearly any other to regenerate you with brand spanking new body parts.

Here is an engineering application of making new body parts in the case of something catastrophic happening to you that goes far beyond the capability of simple nutrition to fix. If this biotech were advanced today, no victim of catastrophe, malice, or accident would ever fret as they could literally be rebuilt with their own cells.

Growing new bones.

Columbia University's applied biology/medicine department are real pioneers - they create biology where it wasn't there before. Others look to "experts" for footing, because they themselves will not be experts. The reality is that everything is demarked and organized that wasn't demarked and organized before by very intelligent people who knew nothing about the field. They become the experts by virtue of their interest and rigor in defining something that was undefined.

Tuesday, March 2, 2010

Gamma delta T-cells and immune enhancement

This is what not to do:Mevastatin knockdown of yd T cell and corroborates independent lab studies that show that statins are immunosuppressive so much that they are considered as anti-graft-rejection drugs in organ transplant.

Priming these cells with drugs are known to potentiate an anti-cancer effect but not without the usual culprit problems like jaw necrosis.

There are other natural and safe compounds which prime gamma delta T-cells, among which are L-theanine from regular green and black tea. The focus has been on polyphenols that have a plasma threshold much lower than their effective dose, when in fact it might be more bioavailable items in tea that are making the immune system stronger rather than a direct cytotoxic effect by molecules. This being said, these molecules with very low bioavailability may have a profound local effect that is overlooked. In the case of the gastric tract, this is not a small surface area, and it is immunologically dense. The effects of polyphenols that are not seen in plasma may actually be at work in the gut, a very large lymphoid and dendritic site in its own regard. Then there are other components like L-theanine.

By modulating these pathways without drugs, one may enhance the immune system safely and naturally against cancer.

Two molecular mechanisms of compensation after heart attack

If the heart survives after an ischemic heart attack, there are ways that it copes. The structural scaffold fibroblast cells remain, after the functional cells have died. These work much harder to maintain the akinetic region which is better than overt rupture, which would be lethal. The rest of the remaining heart undergoes stress and strain to maintain the difference in work, but at a cost.

Distinctive ERK and p38 signaling in remote and infarcted myocardium during post-MI remodeling in the mouse.