Vitamin C and Cancer - The Research Isn't Finished.

New evidence shows very different mechanisms of action than that expounded about, such as pro-oxidant and antioxidant effects, pro-drug effects, immune side effects, tumor side effects, stromal effects, epithelial to mesenchyme transition effects, and useful fibrosis.  The last mechanism, reliant on dense collagen meshes from the "schirrous response" or foreign body response is the same an oyster does to a grain of sand, except instead of pearl, the human body uses collagen.  Sometimes, the tumor turns into a fibrous, benign cyst.  Other times, the stroma prevents TIL from approaching it.  Certainly, when a tumor is free to break away from the primary, it makes for more metastases, which is what makes cancer so lethal.  No doubt the capsule buys more time, even with a very vascularized tumor.  Pauling noted a new compound made, between ascorbic acid and the cements between cells that inhibits hyaluronidase, which dissolves the cement and allows tumor cells to spread.  This enzymatic inhibitor was called a physiological hyaluronidase inhibitor, PHI.

"It now seems clear that the active component of PHI is a tetrasaccharide with a terminal glucuronic acid unit replaced by an ascorbate residue, resistant to exoglycosidase activity, and therefore capable of blocking the whole process of glycosaminoglycan depolymerization." Cameron, et. al 1979

There was no compelling body of work since then to prove or disprove the in situ generation of such a PHI around tumors that required vitamin C to be made.  As in zero papers since then.

In 2023, epigenetic reprogramming, a reset mechanism, was discovered.  This isn't ammunition for the loony bin and death bed burglars of Linus Pauling to scream in vindication.  Hardly so, for this discovery isn't theirs and they claimed all sorts of outlandish buffoon thoughts.

 Vitamin C boosts DNA demethylation in TET2 germline mutation carriers

Copper Deficiency Can Cause Heart Failure

Here is some good science out of the British Medical Journal that will spare a lot of good people from a lot of bad grief, mysteriously caused by a simple lack of dietary copper.

Copper deficiency may be a leading cause of ischaemic heart disease 

 

 

Ethics in Medicine

If our primary goal is to improve the human condition, then propagating suffering is the antithesis to it.  Any behavior that breeds more harm against the oath, "Thou shall do no harm," demonstrates an active flaunting of the ideals of medicine.  A self knighted "Health Foundation" must first actually refrain from harming hundreds of people before seeking out to deploy antique empires in far off places with a favorable international exchange rate where a peanut at home is a pound afar.

It is not a psychiatric playground to ruin yourself and everyone around you in a pyrrhic loss, not even a pyrrhic victory.  You leave that psychological baggage at the doorstep before you enter the hallowed halls of medicine.

It is not a place of judgement and social engineering.  This is not a wooden puppet theater.  This is why there are such explicit protections for belief, orientation, physical traits, gender, etc.  It applies to everyone, not just someone who thinks they are the prince or princess of the building.  I would privately joke about people carrying such fruity airs of faux royalty by prefacing their name with "King" _so and so__/  Even real royals, one who actually visited me from overseas, are not so self-absorbed.  Medicine is meant to heal ailments of the body and mind, not create more of them.

It is not a place to put your ego above the life and death reality of your words.  If you insist on erroneous ideas such as opposing the covid-19 vaccination campaign that has more or less restored normalcy to American life, what you do is indirectly mass murder people by encouraging vaccine denial, thereby allowing the covid-19 virus to be so much more severe and dangerous.  The vaccine turns a once deadly new plague into something like an old cold or flu.  Nobody is going to lug around the mountains of herbs and pints of oils with them all the time in case they catch covid-19.  It is simply more practical to upgrade everyone's immune system to be effective towards covid-19 all the time, without need for reactive herbal extracts which fresh supply you must have on standby at all times - great business model.  Moreover, those magic elixirs factually have not been tested in humans with covid-19 for effectiveness, patent or no patent.  The right to access over the counter herbs, vitamins, minerals, and natural supplements should exist and be maintained as a uniquely American right towards personal health, but these materials should not be construed as a cure without testing them as one first.  To suggest that a patent replaces a clinical trial fools nobody of importance or influence in legal medicine.

It is our place as scientists and those involved in the science to treat it with the utmost sense of responsibility it deserves.  Although the day to day should not be treated like a constant emergency, but with the appropriate amount of urgency or even calm, the fact is that we are dealing with the matters of life and death for some.  It is not a joke for people who have cancer, heart disease, brain ailments, or permanent infections.  It is not a joke for those who have been cosmetically disabled by a disease.  It is not a joke for those whose body is crumbling from underneath their mind long before natural old age.  It is not a game, and for those who abuse and have abused the channels of science as merely a game should read over this from the beginning to the end a few times.

Setting Matthias Rath's erroneous claim to Vitamin C Therapy for Atherosclerosis straight for the record for history beyond 2022

When Matthias Rath sued Linus Pauling for his alleged original discoveries in the 90's, The Court Law in the USA dictated that whoever was first to discover the application was the legally entitled bearer to patent protection.

At the time Matthias Rath sued Linus Pauling, the first to discover vitamin C as a way to prevent occlusive arterial diseases, atherosclerosis, so on an so forth was neither Linus Pauling or Matthias Rath, but Constance R Spittle.

The automatic legal machinery then, now, and today would negate and reverse all and every of Matthias Rath's purported legitimacy as holding this intellectual property.  How this ruling was made at all points to a complete ignorance in the history of this body of discovery by The Court, probably through sheer ignorance, as the "internet" and "cloud" were not availed to The Court until after these errors.  As of 2022, we can see that all and every of Matthias Rath's claims against Linus Pauling were and are invalid as by global law.

Vitamin C's three mechanisms in preventing human atherosclerosis (Constance R Spittle, June 13, 1974)

 

 

 

 

The Ultimate form of "Gaslighting" by Putin:

Attempting to override any sense of logic by means of hypnosis and trickery, Putin offers dozens of excuses of why he pre-emptively invaded Ukraine without any threat to Russia from Ukraine or NATO.

In fact, President Biden had willingly offered to support Nord Stream 2, which by default meant NATO protection of Moscow petroleum assets.

Through Putin's crazed, irrational actions, thoughts, and behaviors, this is no longer possible for Russia, and only Putin is to blame for this insanity.

 

Facts:

1) Ukraine was never a member of NATO.

2) Had Ukraine joined NATO, there would still be zero threat to Putin, but actually, increased security of its oil assets (Nord Stream 2) enriching Moscow and feeding Europe.  NATO, unlike Putin, has zero land grab motivations in Ukraine or continental Russia.  Putin has lost his mind.

3) Putin invaded Ukraine.  NATO did not invade Ukraine or even wish to.  NATO never wishes to invade Russia or Ukraine.

 

What the world must realize is that there are suicidal groups who wish to goad on a WW3.  Neither Biden, NATO, Z, or anyone else in the governance of Europe, USA, Ukraine, and probably Moscow want a world ending WW3, and this is what it will be.  Even those innocent nations who are not involved will be poisoned beyond the ability to sustain anything but the most primitive radiation resistant life forms.  Even radiation resistant humans will perish forever.  No humans will survive WW3, and as history will see it, it will have been the most stupid, shameful failure, proving our delusion in the belief of ourselves as better than a monkey with a nuke in its hand false.

Obviously, the worst thing for global human health is WW3.  Nothing could come close to the decimation that will follow, even indirectly, by WW3.  The suffering will eclipse WW2 unimaginably.  As a global health aim, stopping WW3 is currently our first priority.

Novo Nordisk models 2 Time Nobel Prize Winner Linus Pauling's Discovery Between Collagen And Human Atherosclerosis

From the groping in the dark to connecting genes to diseases, Linus Pauling brought the world greater clarity and visibility in biological science.  He was a very intuitive character, pulling things out of the blue which were often correct.  One of his conjectures was that the human collagen synthesis pathway and the lack of the most critical element to this, ascorbate (pronounce it how you will, it is always spelled ascorbate) somehow was the driving force for the majority of human atherosclerosis developed over decades in a lifetime.  Rather than being a sudden, overnight phenomenon where a lump suddenly appears and you keel over from an LAD plaque burst, thrombotic, ischemic "widow maker," these bumps in the artery form over the period of years.  You can even suffer a bunch of these over weeks, and they still won't kill you outright.  Likewise, you don't need any unstable bumps on your arteries for a pothole in the endothelium to cause the same thrombus event by revealing a platelet sticky, damaged basement membrane.

Linus Pauling, being an expert on helical things, found that collagen, a helical thing, is the basis for healthy arteries.  Old histopathology stains are not able to reveal the medial and subendothelial compartment collagens, and so for many decades, many pathologists considered collagen unimportant to arterial integrity until it was glaringly obvious in a fibrotic scar of a plaque.  The Trichromes and Elastin Van Gieson stains in particular generally only detect the adventitial collagen and nothing inside.  The EVG stain suggests that there is perpendicular collagen between the SMC cells, but does not mark the subendothelial collagen.  Where's the collagen???  It is definitely there.  The strongest collagen jacket of an artery is the adventitial layer, so when you have problems there, the artery is in deep trouble.  Some dismiss the adventitia, the collagen jacket of arteries as unimportant to the etiology of atherosclerosis, but when you consider that arteries themselves are fed by arterioles entering and fed through the adventitia, the collagenous adventitia presents itself as essential to the the inner lining health of the artery.  Very simply, all the collagen in an artery is important to its health.  Later immunohistochemistry and EM IHC would clearly show that collagen is a critical structural element in every layer of the human artery.  

Even fibrosis, which is the human body's way of filling in voids of dead and missing cells with a neutral element, rather than leave a giant hole through which massive inappropriate leaks occur, is a life perpetuating phenomenon for the artery and all organs in the body.  A defective, non-functional, excess collagen patch is exceedingly more beneficial than a hemorrhage or even worse, thrombosis hole, in the mathematics of the automatic human biology.  Very imperfect, but also perfect given that sometimes cells cannot divide fast enough to replace a massive loss of them.  

So which one of the many collagens is so important to arterial health, and which is the intersection between Linus Pauling's vitamin C-arterial collagen-arterial health idea?  Col4, which like all collagens requires vitamin C for its integrity.

Novo Nordisk identifies the specific collagen subtype preservation and restoration needed to prevent atherosclerosis (Col4)

Specifically, Linus Pauling cited the amounts of ascorbate that Gulono-y-lactone-oxidase carrying vertebrates are able to upregulate in times of stress that virtually never succumb from heart attacks, strokes, aneurysms, and the rest at the half point in their lifespan.  In these vertebrates, it is totally unheard of for an animal at the equivalent of a human 65 years old to suffer a heart attack, even considering their massive overbearing genetic excess of HDL over LDL.  Eventually, the lack of heart cell regeneration may give way to natural fibrosis and a natural lifespan end, where the heart gives out, but this is not the result of obstructive dietary cholesterol but an innate evolutionary clock.

But there must be a reason for the relative excessive ratio of LDL over HDL in the human organism.  Sri Lankan elephants for example, seem to only have HDL, and are huge vertebrate mammals.  It suggests that an overbearing ratio of LDL to HDL is tantamount to intellectual evolution, pointing to the criticality of cholesterol to the brain at the expense of arterial health.  A true conundrum presents itself, considering that the brain needs its arteries.  A very strange "what if" presents where the insulation upon axons is not cholesterol, but an artery friendly molecule.  In a very vague, out of focus view, what insulation compound is mission critical to the nervous system of vertebrates is needed in a vast excess compared to its dual role in membrane and cell cycle of arterial cells.  Very simply, the amount of cholesterol needed in the brain is far beyond what is needed in the artery, and important amounts of collagen are there in very specific orientations in health.  If the compounds for axon health and artery health were independent, then two things could be made and this problem of one thing being helpful to one system and harmful to another system solved.  A very absurd request of evolutionary processes which for humans are slow - thousands of years.  We're talking about completely re-engineering the lipid genetics of humanity.  In the meantime, we can pull up and pull down our levers with medicine knowing all this.  Is it futile?  NO.  A short, perfect, benevolent life is better than a short, terrible, malevolent, life for humanity.

So if we all plan to live forever, we have to figure out how to both steel our arteries against its pot hole plaster cast, cholesterol, without starving our brains of cholesterol.  It's a true conundrum.

In ending, Linus Pauling's specific recommend for large human adults was no less than 6,000 mg of vitamin C throughout a day, not in one dose but divided throughout a day to at least avoid atherosclerotic problems without other pharmaceutical interventions, specifically to enhance collagen repair within the artery.  Which collagen he didn't know, but Novo Nordisk identifies this to be Collagen IV(4).

   

The Vatican Openly Recommends All Global Citizens Obtain the Covid-19 Vaccine

 I never mix religion with science as it is bad practice for both spheres of human activity.  Often times, people, wretched, miserable, dishonest, and evil people wear it as a badge of authority.  "I am a devout Catholic so I can do this evil thing to you and have their commission to do it."  Nope.  Sorry.  It's people like these, these moral frauds, liars, and hypocrites, who like suicide vest bombs are so destructive to society and organizations whose sole aim is to build a better human being, a better humanity, and a better world, free of any MALEVOLENT personal insanity quests.

One group goes to Catholic Church regularly but in private are filled with stupidity and malice towards the world, going so far as to suggest that the Vatican denounces covid-19 vaccinations or questions them in any way.  Until the poor in every country load up with expensive (to them) inhalable flax seed oils they constantly carry and inhale, have a satchel of extremly overpriced for-profit non-profit herb extracts and lice medicine they carry with them at all times, constantly nipping at these potions and poisons, wait! nope.  They are not even known to work in a real life setting.  This sort of false hope sets into motion hesitation, in the belief that when someone contracts covid-19, all they will have to do is drink flax oil.  It will be no mystery when these misrepresented scientists, and there are scientists in The Vatican, peacefully turn their backs on those who kill and murder by the spoken and printed word.  "Thou Shall Not Kill," "Thou Shall Not Lie," "Thou Shall Not Steal," and "Thou Shall Not Envy" are the basics, taught to any kindergartner, and so these indirect mass murderers are essentially at the moral evolution and maturity of pre-kindergarten level, deserved of poorly drawn Fisher Price crayon and Etcha-Sketch caricatures.

The reason many scientists enter the field is a form of grand sacrifice in the hopes that their efforts will improve the human condition and the human experience on Planet Earth.  In that way, they share traits with teachings found in the major religions of the world.  Ending this entry is a return to basic foundations of science, free of irrational and illogical thinking where religion is its own domain where science should not enter, and vice versa.  However, when the two meet in common ground, the entire world benefits from a purely BENEVOLENT intersection of good intentions and value free technicalities.  As you see below and beyond, I am no opponent of natural medicine or vitamin C.  You might even get the mRNA or old type vaccine AND take vitamin C or flax oil or whatnot as I might do.  There is not any rational "either or" proposition, just an irrational, crizazy-insane "either or" proposition. 

To be clear, I obtained the covid-19 vaccine and state tbat vaccination for covid-19 is the only solution that will end this abnormal way of life.  My friends and closest who have received this vaccine have little reason to fear covid-19.  Those who have not been vaccinated beyond age 40 with a perfectly good health basis will spread or die of covid-19, however much flax oil or lice pills they take.