New evidence shows very different mechanisms of action than that expounded about, such as pro-oxidant and antioxidant effects, pro-drug effects, immune side effects, tumor side effects, stromal effects, epithelial to mesenchyme transition effects, and useful fibrosis. The last mechanism, reliant on dense collagen meshes from the "schirrous response" or foreign body response is the same an oyster does to a grain of sand, except instead of pearl, the human body uses collagen. Sometimes, the tumor turns into a fibrous, benign cyst. Other times, the stroma prevents TIL from approaching it. Certainly, when a tumor is free to break away from the primary, it makes for more metastases, which is what makes cancer so lethal. No doubt the capsule buys more time, even with a very vascularized tumor. Pauling noted a new compound made, between ascorbic acid and the cements between cells that inhibits hyaluronidase, which dissolves the cement and allows tumor cells to spread. This enzymatic inhibitor was called a physiological hyaluronidase inhibitor, PHI.
"It now seems clear that the active component of PHI is a tetrasaccharide with a terminal glucuronic acid unit replaced by an ascorbate residue, resistant to exoglycosidase activity, and therefore capable of blocking the whole process of glycosaminoglycan depolymerization." Cameron, et. al 1979
There was no compelling body of work since then to prove or disprove the in situ generation of such a PHI around tumors that required vitamin C to be made. As in zero papers since then.
In 2023, epigenetic reprogramming, a reset mechanism, was discovered. This isn't ammunition for the loony bin and death bed burglars of Linus Pauling to scream in vindication. Hardly so, for this discovery isn't theirs and they claimed all sorts of outlandish buffoon thoughts.
Vitamin C boosts DNA demethylation in TET2 germline mutation carriers
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