"Conversely, stimulating TET activity by systematic injection of its co-factor, ascorbate/vitamin
C, increased chemokine and TILs, leading to enhanced anti-tumor
immunity and anti-PD-L1 efficacy and extended lifespan of tumor-bearing
mice."
Vitamin C has a newly revealed MOA. It is the rate limiting substance for TET2 activity, and therefore it is a bonafide immunotherapeutic small molecule.
B.S. in Biological Sciences, Stanford University 1998
Over 20 years of bench experience within academic, corporate, government, and private laboratories in basic biochemistry discovery, microbiology, cancer therapeutics, cardiovascular disease, and other areas. Involved in study design and implementation as well as data analysis.
Many publications within PNAS, JACS, etc. and numerous abstracts within the field of cardiovascular medicine from the SF VAMC via NCIRE and elsewhere.
2015 - John C. Cha. Impostors, Capgras-ians, and reverse Capgras-ians beware.
Citizenship: USA
