Lysine and (+) Catechin disable melanoma cells from establishing metastases

 (+)-Catechin in a 1:2 Complex with Lysine Inhibits Cancer Cell Migration and Metastatic Take in Mice

 

10uM preincubation for 6 hours before inoculation into the mice.  This is different from establishing a xenograft and administering catechin:lysine orally.  They openly state that the anti-metastatic activity is independent of a lack of cytotoxic effect, attributed to EGCG, but not catechin. 

 

 

Then one would ask, is 5-10uM Catechin achievable in the blood?   Yes.  Is 5-10uM lysine achievable in blood?  Yes.

One could imagine a solid tumor, when constantly bathed in this complex in a live mammal, would encounter this effect described.  

 

The next step would be to administer this complex by IV catheter and in an oral formulation in mice with established solid malignancy and check for met burden in non-hormone driven malignancy.  I guess that hormone driven malignancies will not respond, but non-hormone driven maligancies will be contained.