No Mevalonate = No new liver cells. Why would I make this up. Too bizarre for me to imagine out of nothingness.
Mevalonate-derived proteins in liver regeneration
The higher end of dosing for statins is ill-conceived. It doesn't do anything other than take a sledgehammer to LDL cholesterol. Lp(a) is still happily made by the liver at the same level, and along with it, Lp(a)'s cholesterol inside it.
That is not the way statins work anyways. When they do work, taken at low doses, it is through non-mevalonate pathway pleiotropic effects discussed in the literature.
The early generation "dirty" statins were so powerful at jamming cholesterol synthesis that they were studied as chemotherapeutics because cells do not divide if they are underneath a threshold of intracellular cholesterol. This body of research is older but easily found.
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