Lack of type XV collagen causes a skeletal myopathy and cardiovascular defects in mice.
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Lack of type XV collagen causes a skeletal myopathy and cardiovascular defects in mice.
Eklund L1,
Piuhola J,
Komulainen J,
Sormunen R,
Ongvarrasopone C,
Fássler R,
Muona A,
Ilves M,
Ruskoaho H,
Takala TE,
Pihlajaniemi T.
Muscle histology: focal areas of degeneration, regeneration, and
variation in fiber size. Hematoxylin and eosin-stained sections of the
gastrocnemius (
A), triceps brachii (
B),
paraspinal (
C), and quadriceps (
D)
muscles of 6-month-old null mice showing cell degeneration (curved
arrows,
A and
C) with macrophage
infiltration (
A), regenerative fibers (thin arrow,
B), central nuclei (thin arrow,
C), and
increased variation in fiber size with atrophic muscle fibers
(
D, arrowheads) compared with age-matched wild-type mice
(
E). Original magnifications:
A and
D, ×300;
B, ×200;
C and
E, ×80.
Ultrastructural changes in capillaries. Electron microscopy of heart
capillaries from a wild-type (
A) and a null mouse
(
B) with swollen endothelial cells (asterisks). The
lumen is indicated by a white arrow. Skeletal muscle capillaries from a
wild-type (
C) and a mutant mouse (
D)
showing luminal narrowing and folding of endothelial cells.
Effect of isoproterenol stimulation on developed pressure in
(
A) 6-month-old and (
B) 12-month-old
mutant and wild-type mice. The responses to β-agonists were measured
in terms of the ratio of the maximal value of the developed pressure
(DP) to the basal level before the isoproterenol perfusion in
Col15a1−/− (●:
A,
n = 7;
B,
n = 11) and
Col15a1+/+
(□:
A,
n = 7;
B,
n = 8) mice. The symbols
represent mean ± SEM. Significant differences between the
Col15a1−/− and
Col15a1+/+ mice are indicated by asterisks
as follows: *,
P < 0.05, **,
P < 0.01. The basal pressure was 31.7 ± 5.0
and 27.3 ± 5.0 mmHg for the 6-month-old control and null mice,
respectively, and 20.2 ± 3.4 and 20.8 ± 2.0 mmHg for the
1-year-old mice (mean ± SEM).
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