Vitamin A Deficiency Causes an Irreversible Immunodeficiency??

Now, let's read this carefully again.  "A significant unresolved question is how vitamin A deprivation causes, and why retinoic acid fails to reverse, immunodeficiency. When depleted of vitamin A, T cells undergo programmed cell death (PCD), which is enhanced by the natural competitor of retinol, anhydroretinol."

But the TV pop-docs told us that vitamins have absolutely nothing to do with immune system function and that this vitamin-immune system connection is some kind of charlatan's ploy..

Wait a minute, now.  Vitamin A deficiency causes immunodeficiency?


Vitamin A depletion causes oxidative stress, mitochondrial dysfunction, and PARP-1-dependent energy deprivation.



While the title says one thing, the abstract clearly states another.  The disease is clearly multifactorial, but one cannot actually claim that vitamin deficiency has nothing to contribute to immunodeficiency because that would be simply false.  In fact, there is a 1-to-1 causality between various single nutrient deficiencies including macronutrients and immunodeficiency.  Nearly all nutrients are important to immune system function in one aspect or another.  It doesn't mean a well-nourished person will never get sick, just the same as living in the USA doesn't mean everyone will win the lottery.  It does mean that nutrient deficiency is an important causal factor to immunodeficiency, especially in impoverished countries and that there is no denying this fact.