1) The ApoE KO mouse.
2) The LDL receptor KO mouse.
(sometimes they use salt hypertensive or STZ diabetic models)
None of these have apo(a) as humans do, and all create ascorbate within their own livers which humans don't do. Another thing to keep in mind is that mice eat 1/4 their own weight ( ! ) in food a day. For a 150 pound human, that is nearly 38 pounds of food a day. This doesn't reduce the validity of the model, but people generally ignore some profound differences between mouse and man. This mouse model is the main pillar of all of cardiovascular medicine for humans.
Subscribe to:
Post Comments (Atom)
No comments:
Post a Comment