This was Linus Pauling's supposition: Ascorbic Acid and the Glycosaminoglycans: An Orthomolecular Approach to Cancer and Other Diseases. Be careful to note that he supposed that ascorbic acid may enhance the formation of a "PHI." Here is the paper.
It turns out that ascorbic acid IS a weak PHI on its own. However, it has never been thoroughly studied to date whether AA does upregulate a PHI, and what exactly this PHI is. There are dozens of basic questions about ascorbate biology that are still left unanswered.
In recent days, Yamamoto has focused on a hyaluronidase family enzyme, the N-acetylgalactosaminidase (NAGAlase) and its interference in changing Gc to GcMAF.
Today, there are brassica vegetable (yes, cabbage, broccoli, and brussel sprouts) originated ascorbic acid scaffold molecules that have been indentified as very potent (uM efficiency achievable by oral dosing) hyaluronidase inhibitors. Ascorbigen is one. While it may not actually be directly cytotoxic to cancer, it may behave in the way that Pauling had hypothesized decades ago.
Indole Derivative
L-Ascorbic Acid 6-Hexadecanoate, a Potent Hyaluronidase Inhibitor
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Recombinant Human Hyaluronidase (PH20) belongs to a family of enzymes that catalyze the degradation of hyaluronic acid and can degrade hyaluronic acid in the extracellular matrix and promote the diffusion of extracellular substances.hyaluronidase
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