Superb Blog of Blog: "Ancient Transporters: HDL and LDL Lipoproteins Carry Precious Cargo "

This is a scientific island of common sense worth visiting.  Extremely insightful and ties together things far apart for an understanding with "range."

http://drbganimalpharm.blogspot.com/2013/03/ancient-transporters-hdl-and-ldl.html

Forced Reading Versus Searched Reading

Some people will spend hundreds of thousands of dollars on forced exposure to an idea.  You have no choice but to look at it, imprinting an idea in your mind, whether you agree to it or disagree to it.  That is one approach.  There may be some big proponents you win this way, as well as big opponents.

On the other hand, the totally free, no money involved Google Blogs only attract people who resonate with your idea.  In essence, you automatically generate 100% support bases by not spending any money, not trying (at all) to attract anyone.  Agree?  Stay.  Disagree?  Okay, you didn't lose anything so don't stick around.  Especially don't stick around and disagree.  I spent $0 on gaining a philosophical support base but that is not the correct or appropriate way to look at things.  More accurately, like minded people eventually resonate toward one another try or not to keep them away from one another.

Or you can try to force the same poles of two magnets against one another, causing only repulsion, to use a metaphor.

In a way, simply typing this forces (somebody) to read this.  I didn't spend anything other than a few minutes and a few electrons doing this.  It only takes one power broker or gatekeeper to agree with you (or disagree with you as it may be) to change the intellectual terrain on which you are received.  By voicing your thoughts (for free, not forcing people to read with hundreds of thousands of dollars), you activate this possibility.  If you don't, what can happen other than nothing changing...

In this regard, I see that there are classically trained and intelligent scientists who are separating the bogus chaff of sales pitches from the drug industry from what is real, and too bad for the drug salesmen, oftentimes the real solution is not a big money maker.  Good for you, you reader!  Congratulations on finding my shared knowledge, you will not regret it but rather free yourself from the exponential chain of bullshit that will cost you lots money, time, and pain.

If you don't agree, just go away.  It is like the Flinstonian obsolete creeky old institution The Freemasons, feebly trying to make a comeback in places like Orange County, CA believe it or not.  The Freemasons don't go out like Jehovah's Witnesses trying to recruit people let alone retain them.  Come and stay, or come and go, or don't come, or stay and go, whatever.  It is totally up to you.  I simply go to a Roman Catholic church and pay my dues in work or support, it is much easier and cheaper.  Humans think they can pay their way into some unknown or worse confuse science with religion which even a priest would advise against.  But as Einstein said, "God does not play dice with the universe."  No, it is intentional. If you are so obtuse not to see these workings, it is no use to force this understanding.  A person changes his or her own mind or heart, there is no other path in intellectual concession.  A person celebrates in "changing someone else's mind."  Ridiculous.  Nobody changes anyone's mind, they change their own.

Bathe your insides with green plant juice.

Why would you do that???

TNF-alpha shreds your arteries and causes plaque to start forming

Chlorophyll prevents TNF-a from doing its business to you.

Therefore, green plant juice may prevent atherosclerosis.

Negligence. Obfuscation. Perdition. Eloquence. = NOPE

As a wise man once said, there is no long term benefit to mediocrity.  If it brings you to a show, helps make money in the short term, but is totally mundane and forgettable, all that will happen is that you as a scientist will have wasted your time, maybe even your entire life into your 60's, chasing after chimeras.  ghosts.  illusions.  nothing.  By that age, it is way too late to "start fresh."  At best, you will be a walking irrelevent obsolescence, rotting by the day to the grave, comfortably but kindly unknown to anybody.

What is worse is when someone intentionally ignores uncomfortable or contrary evidence.  Not refutes, but ignores.  Refuses to even read and acknowledge.  Then obfuscation, which some quackademians are experts at, leaves a smoke screen so thick that some people give up trying to understand them, leaving them to go their merry but incorrect way.  Of course, if these people are wrong, fallacious, or inaccurate, it is simply a matter of time before the world makes fools of them, flying them like a flag for others to ridicule.  In this way, perdition is the fire under every good scientist's ass that should make sure they are honest.  I feel the heat everyday and this does make sure that I never even entertain the thought of "fudge factor" or some white lie.  Even the most eloquent liar eventually gets turned up as a ridiculous fraud which is why I would never attempt such a moronic thing.  Such charlatans get written up in history to be ridiculed FOREVER.

Yet others do, for short term benefits or whatever.  Not me.  N.O.P.E.  If someone tries to stuff words in my mouth, I will swiftly and sternly correct their dishonesty in a very public way.  Have a question about my work? Ask me directly, not some crazy second-hand competitor. - John C. Cha

Don't let the clowns of NOPE tell you what I think as they do not know what I think.

Do not take Vitamin D for flu prevention?!? A world gone mad and dishonest.

Epidemic influenza and vitamin D

With a clear link to Vitamin D deficiency and influenza having been established by the most credible doctors and scientists to have existed, we have the same message being thrown at us:  Get flu shots.  Just in time for "flu season" which really coincides with: temperature decrease, aridity of nasopharyngeal mucous membranes, and Vitamin D deficiency (not a weakened flu virus injection deficiency).

As in literally, weakened whole flu virus and sometimes some bonus mercury if the needles were bundled in packs rather than individually.  A lot of dummies think that the flu shot is a special medicine, antibody, or nanobot going around inside you plucking off the influenza virus.  The flu vaccine IS the flu virus.  As these rigorous and conventionally trained doctors and scientists documented, Vitamin D deficiency caused this flu virus jab to spring into action and cause flu symptoms.  The symptoms were minimal to none with lots of Vitamin D.

Yet, because Big Pharma thinks we are morons and only potential consumers, they will try to persuade us to part with our money in any way imaginable.  At the top of these industries, literally the only thing that matters is money.  Murder is just fine if it means preserving a financial domain.  It is not a second thought.  If that is okay, then the other things seem like saintly occupations by comparison.  What what it be to them to lie to you about efficacy, side effects, or reason of being (money)?  As all (ethical) global intelligence agencies do, they follow the money to end at the real source of crime.

Cholesterol does not cause atherosclerosis. Oxidized cholesterol byproducts do.

Here are a few things to keep in mind:  1) Cholesterol is not soluble in water or blood.  A derivative of cholesterol that is soluble in blood or water is not cholesterol.  2) The only way cholesterol is moved around either in the blood or as an adduct is by the action of adding a hydrophilic protein or converting free cholesterol enzymatically to a soluble form.  3) The only way cholesterol gets to an artery wall is through a lipoprotein or the soluble form made first by a cell's action upon ingested cholesterol.  4) It has already been proven that native LDL is harmless to endothelial layers even in very high concentrations of the particle and that the oxLDL particle is the one that causes havoc to the endothelial layer.

That being said, even in the most severely diseased coronary artery disease (CAD) patient with acute coronary syndrome (ACS) presenting as angina, respiratory problems, and/or MI, the level of oxLDL is 4-5mg/dL maximally.  Normally, they are half this value to none.  This value of 4-5 doesn't occur until after the coronary artery disease, so how could it be that oxLDL caused the CAD?  Temporally, and logically, oxLDL could not have caused CAD if it was absent beforehand.

There is no question that toxic adducts of cholesterol DO cause arteriosclerosis and the consequence is atherosclerosis.  Is it an inevitable event that cholesterol becomes 25-hydroxycholesterol and cholestane-3beta, 5alpha, 6beta-triol, the culprits of endothelial aggravation?  No.

It is not cholesterol, it is OXIDATION that causes these culprit oxidized cholesterol molecules to arise and cause harm.  By having administered pure non-oxidized cholesterol to the artery cells with no harm, scientists made sure of the fact as early as 1976.  Extending the first post, here are younger studies confirming the first.

Effect of auto-oxidation products from cholesterol on aortic smooth muscle cells: an in vitro study.

Cytotoxicity of oxidation derivatives of cholesterol on cultured aortic smooth muscle cells and their effect on cholesterol biosynthesis.

Ironically, the hydroxycholesterol and other oxygen adducts shut off cellular cholesterol synthesis, making the matter worse as your cells, especially the fastest dividing ones, make it for a mission critical reason.  As the repeat, "Purified cholesterol showed no cytotoxic effect and minimal inhibition of cholesterol biosynthesis"

Inhibitory effect of cholesterol oxides on low density lipoprotein receptor gene expression.

Again, after two decades, the groups repeat that ". Pure cholesterol showed only minimal inhibition."

The question of importance is how much of the toxic oxygenated cholesterol is there in food?  Who would know for something boiling around in hot oil and open air for weeks?  My guess is a significant amount of cholesterol has turned to ox-cholesterol and probably stuff like that should be avoided.  Minimally cooked foods, or fresh foods would have a minimum of this toxic cholesterol derivative.  So indeed, the way meat is cooked may be a significant way to introduce these cholesterol-oxygen problem compounds in the blood, and these are indeed soluble.
 
However, like most everything, there is a reason for this artery aggravating 25-hydroxycholesterol (immune response against viruses) to exist:

Armand-Frappier Outstanding Student Award--The emerging role of 25-hydroxycholesterol in innate immunity.

25-Hydroxycholesterols in innate and adaptive immunity.

There is an enzyme that responds to interferon by hydroxylating cholesterol.  25HC is antiviral.

Given that your blood levels of ApoB bound cholesterol are from your liver and not from a vat of oil boiling around for weeks, it would not cause any arterial injury.  This is dependent on antioxidant functions preventing oxidation.  These are enzymatic, such as PON and glutathione, and enteral/parenteral such as Vitamin C, E, and A.  

Pure cholesterol versus oxidized cholesterol and the role of antioxidants.

Now this is interesting.  "Purified cholesterol at the same dose produced no effect."  This painstaking chemistry is rare and goes to show that you can call something cholesterol, but it may not actually be cholesterol.  All these oxygen adducts of cholesterol and other junk are very aggravating to the artery, causing "intimal, fibrous lesions without foam cells or hypercholesterolemia" the sort of thing you might see in advanced scorbutic lesions of the artery wall.  This probably pertains to cheap Vitamin C too, which might contain some harmful junk.  Pure Vitamin C of good quality, not questionable and impure, is probably as important.    

Arch Pathol Lab Med. 1976 Nov;100(11):565-72. Angiotoxicity and arteriosclerosis due to contaminants of USP-grade cholesterol. Imai H, Werthessen NT, Taylor CB, Lee KT. Abstract Impurities were concentrated from several lots of cholesterol by recrystallizing cholesterol from methanol solution, retaining the mother liquor, and evaporating the residuum to dryness under vacuum. This concentrate contained the products of spontaneous oxidation of cholesterol and other contaminants from the original source. The concentrate increased the frequency of dead aortic smooth muscle cells and induced focal intimal edema in the rabbit 24 hours after gavage at 250 mg/kg. New or old cholesterol was similarly angiotoxic, the old more so than the new. Cholesterol purified via dibromination induced an increase in aggregate debris in 24 hours at 250 mg/kg but no increase in degenerated cells. The concentrate administered at a total dose of 1 gm/kg/seven weeks induced intimal, fibrous lesions without foam cells or hypercholesterolemia. Purified cholesterol at the same dose produced no effect.

The problem with food is that unless you keep it under nitrogen and don't cook any of your food, invariably there will be some oxidized cholesterol products.  My arteries balk at the sight of this crud.  The good news is that unlike the experimental condition above and in other experiments adding oxidized cholesterol, there isn't a whole lot of it in what you eat unless you exclusively eat low quality fast food that is fried the hell out of in oil that recirculates and boils in the air for sometimes weeks at a time, which is like an oxidation factory.  Then you might worry some about oxidized cholesterol.

The good news is that there is an enzyme that can prevent LDL oxidation called paraoxonase.

Paraoxonase active site required for protection against LDL oxidation involves its free sulfhydryl group and is different from that required for its arylesterase/paraoxonase activities: selective action of human paraoxonase allozymes Q and R.

The reality is that cardiovascular disease is rampant in industrialized nations where there is plenty of fruits and vegetables available 365 days a year.  If apples and oranges were the cure for heart disease, there would be no heart disease in the US.  By logical deduction, it is not a lack of orange or apple, but something else.

Like a broken record, many scientists the world over have implicated that the human need for Vitamin C and other essential nutrients is much greater than what the RDA maintains, and unfortunately what food can deliver.  Unless we all start eating a whole bunch of acerola cherries all the time, for example, you would need to eat 30 oranges a day or drink the equivalent of fresh squeezed juice to get a modest 2.7 grams of ascorbate.  The whole point of the idea of vitamins was to cover what nutritious food, like oranges and apples could not provide, especially given that trees only fruit 3-5 months a year, leaving humans ravaged by scurvy during the non-fruiting season, therefore creating the situation "cyclical scurvy."  When Vitamin C containing fruits and vegetables are available in the growing season again, the atherosclerosis accelerates during this period, not reduces, in order to build a more scurvy resistant arterial wall.  You want to have a consistent optimal dose at all times.

Now that was a tangent, but not really, as serum antioxidants like Vitamin C have everything to do with preventing cholesterol oxidation and enhancing PON function.  The understated and amazing observation made in 1976 is that purified cholesterol, free of oxidation products and contaminants, is harmless to the artery wall.