There are cells that sit in your bone marrow and other places that when activated and enter your bloodstream are called "Circulating Stem Cells." All of us have a set of progenitor cells that can become various new tissue called mesenchymal stem cells, endothelial progenitor cells, and stem cells that become tissues everywhere. A general term for these stem cells inside everyone already born is "adult stem cell."
Vitamin C and E supplementation with athletic training literally gets your blood flowing, and more of your own adult stem cells enter circulation to home into injury sites and repair them.
"1. Free Radic Res. 2008 Aug;42(8):754-62.
Antioxidants increase number of progenitor endothelial cells through multiple
gene expression pathways.
Fiorito C, Rienzo M, Crimi E, Rossiello R, Balestrieri ML, Casamassimi A, Muto F,
Grimaldi V, Giovane A, Farzati B, Mancini FP, Napoli C.
Department of General Pathology, Division of Clinical Pathology,Excellence
Research Center of Cardiovascular Diseases, II University of Naples, Naples,
Italy.
To date, there is no report on the effect of antioxidants on endothelial progenitor cells (EPCs). This study shows that in vitro incubation of EPCs with vitamin C and E reverted the already well documented lowering effect of TNF-alpha on EPC number and increased p-p38 expression levels. In order to document major changes of gene expression levels and gain insight into signalling pathways, microarray analysis was performed and a significant variation of the expression of 5389 genes in EPCs following antioxidant treatment was detected. Also in vivo evidence is provided about the positive effect of antioxidant vitamins on EPCs, since vitamin C and E supplementation potentiated the physical training-induced increase of EPC number and VEGF levels. Together, these data indicate that antioxidant treatment ameliorates EPC number and causes major changes of gene expression within these cells in vitro. Furthermore, concomitant antioxidant supplementation and physical training in vivo raised the levels of circulating EPCs and serum VEGF more than physical training alone.
PMID: 18712633 [PubMed - indexed for MEDLINE]"
There are other natural ways to get your repair white blood cells into circulation from your bone marrow too. The trick is to get only as much as you need, when you need them, without collateral inflammatory damage. You need cytokines for these to exit their homes and march to their destination, but cytokines can also elicit collateral damage from an indiscriminate inflammatory response.
Sunday, November 21, 2010
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